It'd be such a great situation for humor, too. I could see Duke being confused at some douchebro being upset at a hot trans chick. lol With good writing it wouldn't even have to be painfully obvious, just Duke making a passing comment about how she looks groovy enough for his bed in response to a negative comment or something. There's always a bar somewhere in those games (ok maybe not the old 2D ones), so it wouldn't even be out of place.