Futurama

You cant just have your characters announce how they feel! That makes me feel angry!

She’s built like a steakhouse, but she handles like a bistro!

Professor: Your tux doesn't fit because you stole it from a boy.

Bender: You mean a man. It was his Bar Mitzvah.

You are technically correct, the best kind of correct.

When they're getting pulled down toward Atlanta:

How many atmospheres can this ship withstand?

Well it's a spaceship, so I'd say anywhere between zero and one.

The spirit is willing, but the flesh is spongy and bruised.

"You can't just sit here in the dark listening to classical music'

"I could if you hadn't turned on the lights and shut off the stereo."

🎵We're whalers on the moon,

We carry a harpoon,

But there ain't no whales,

So we tell tall tales,

And sing this whalin' tune! 🎵

Wait, I'm having one of those things, you know, a headache with pictures.

Farnsworth: Dear Lord! That's over 150 atmospheres of pressure!

Fry: How many atmospheres can the ship withstand?

Farnsworth: Well, it's a space ship, so I'd say anywhere between zero and one.

Good news! It's a suppository!

Don't you worry about Planet Express

Let me worry about blank.

Bender: "So people will actually pay money to find love...? I have an idea, an idea so genius...." gavel sounds "Stupid anti-pimping laws!"

Thus global warming was solved, once and for all.
But....
Once And For All.

If I don't survive, tell my wife, "Hello".

"If it's a lesson in love, watch out; I suffer from a very sexy learning disability. What do I call it, Kiff?"
―Zapp

"[Sigh] "Sexlexia""
―Kiff

"If we hit that bullseye the rest of the dominos will fall like a house of cards. Checkmate!"

So, there's an infinite number of parallel universes?

No... just the two...

Tie between:

If anyone needs me, I'll be in the angry dome

angry muttering as the PES flies away

and

Well Susie, it isn't foreigners, it's global warming

Gwabu wabu?

Uh, sure...

"What are those disgusting creatures?"

"Those are the Grungalungas."

"Tell them i hate them."

“We know nothing about their history, their language, or what they look like, but we can assume this: they stand for everything that we don’t stand for. And also, they told me you guys look like dorks.”

No I'm... doesn't!

(destructive noises) Buddha, Zeus, God, one of you guys, do something! Satan, you owe me!

They say the key to any successful battle is the element of surprise. SURPRISE!

My absolute favorite: You win again, gravity!

Not exactly an iconic line, but I love the delivery:

"Have you heard of the Monks of Deshuba?"

Fry: "I've... not heard of them."

Futurama's great for nerdy science gags, social satire, and pop culture spoofs, but its best jokes are always uniquely stupid twists of language like this.

My lead pipe hurts.

There's not a restaurant built that I can't fly - Zap Brannigan

I'll start my own amusement park with blackjack and hookers. In fact, forget the blackjack.

And Fry, you've got that brain thing!

• I already did!

To shreds, you say..

Well, how's his wife holding up? To shreds, you say...

Its actually from that same scene; "NOW I AM LEAVING EARTH FOR NO RAISIN!!!" I often say "for no raisin!!!" in my daily life. :)

The one I use most often: "I've heard worse excuses to drink".

“They’re like sex except I’m having them”.

My only regret is that I have boneitis

What makes a man turn neutral?

When you do things right people won't be sure you've done anything at all.

"Thanks to denial, I'm immortal!"

"What really killed the dinosaurs?" " ME!!! "

"But you're better than normal! You're abnormal!"

I can wire anything directly into anything! I'M THE PROFESSOR!

I sublibed with obly tribial blain dabblage.

"I'm going to remind Fry of his humanity, the way only a woman can."

"You're going to do his laundry?"

Edit - the one that had me literally rolling off the couch because I was laughing so hard was, "That just raises further questions!"

MY LEG FEELS FUNNY

...

MY LEG FEELS BETTER

“Take the deal, Fry! If there's a delicious cake, isn't it better to have one slice than none at all? Even if four other guys eat the other four slices, and they're all thrusting their sweaty naked bodies against the cake?”

Your mistletoe is no match for my TOW missile!

"I'm having one of those things! You know? A headache with pictures"

"... An idea?"