This is a great review. It tells me if there is a deal breaker, say a wildly obvious plot hole, as well as giving some of the impact and experience of the movie. The conclusion is a simple number out of ten, along with a verbal recommendation. 9/10, good review, worth a quick read.
There are three genomes that go into an embryo. One from the chromosomes of the large gamete, the egg, one from the chromosomes of the small gamete, the sperm, and one from the mitochondria, in humans from the egg as well. If you had two XX donors you could make XX kids. If you had two XY donors you could make XX, XY, and YY variants. The only viable ones would be XY and XX, YY would not reach gestation.
That said, if you took the DNA from gametes from each, removed the nucleus and mitochondria of an egg, added the total gametic DNA from both to the cell, added a mitochondria from either donor, then it should, in theory, be a viable egg like in IVF. This is actually a strategy for dealing with a mitochondrial disease by donating mitochondrial DNA from another source rather than those impacted by the disease. The problem would be there are many ways for this to go wrong and be left with an unviable embryo, so it would likely take many many eggs and many many donated cells to get a single viable egg with the donated DNA. That said, it could technically work.
I don't have photos of myself on the internet and do not participate in group photos. If I see a photo of myself online I know, for a fact, that the person who posted it does not respect my privacy, therefore they do not respect me. I will not trust them with any information about myself and others and in general will cut them out of my life if at all possible. Because of this I don't have people who violate boundaries they don't share, so if I said "Actually, I think I may be a woman" or "I have been thinking about leaving the country" they would not immediately judge or try to prevent my doing so, they would let me be and respect my needs. Also because of this I am much more comfortable working on things with these people to make life better and to invest in their wellbeing.
If you want a podcast about conservative approaches to food may I suggest
Perfectly Preserved Podcast
And the fashion, oh wow, such an aesthetic.
I work in disability support so I may use various creams while massaging, I get messy while helping people with washing and toileting, and I feed people which can get messy. I also help people with their yards, cleaning their house, washing their pets, whatever they need.
I would second this. My partner was on an anticonvulsant for a bipolar diagnosis. Why? Because it is used, at a lower dose, as a mood stabiliser. She had limited effect at the sstandard dosage, so the psychiatrist went up in dose to get an effect.
Ultimately she got off all of the meds and is doing better without them, but that is her and her experience, the meds may be useful for some people and not others.
Conditions that are on the label are the conditions the medication is intended to treat, in this case mild to moderate depression. Off label would be using a medication for something else, like using an SSRI to treat hot flushing in menopause or antipsychotics as a sleeping aid. Technically it may work, but the studies are not there to back it, evidence is poor, so it is not shown to he effective and may have associated harm.
Well it depends too on how long things take to settle out. Salt is easily suspended in water, but silt is not, so the water would be salty but not muddy. The water would also probably have lots of photosynthetic bacteria/algae in it, so you would probably have blooms of green, blue, red, and brown all over. Those blooms would uptake light and carbon through that process then as they died drop the content down the long water column. All sorts of feeding below that would create a full eecological web. If there were deep sea vents, volcanic activity breaking through the sea floor, you would have a second source of energy and chemistry at the bottom. That said, the over level of life at the surface would be limited by things like iron, phosphorus, copper, and so on. Any heavier ions would be less available at the surface because there is no surface erosion bringing them in at the top so as they are bound up in dead algae they will drop to the floor.
The rate limiting at the sea floor will be based on energy but not too bad, you would likely see a lot of diverse life around vents and it would have a fairly large complexity over time. That said, the depth would make for less complex life due to the lack of light and associated vision. Some things would make light but it would be dangerous to make and would not be super common.
Another interesting consideration is the geography of the sea floor. Would there be fault lines? If there are continental plates but way under the ocean they would still have movement, so subduction and so on would play out, so you would probably have chains of vents along the diverging or merging plate boundaries. Life would spread along these lines, so life would be closely related at nearby vents but distant over the surface of the planet. I would anticipate a fairly heterogeneous population over the surface of the planet in the deep, but far less so at the surface.
It depends on the composition of the planet. If it is just a massive ball of water floating in space then it will be whatever purity that is, plus whatever space dust and impactors bring in.
If it is basically a terrestrial planet with water on top, say earth plus a lot of water, then it would be salty. The thing with salt water is contact between the water and rock. If there is sufficient heat it will circulate, so salty water from the bottom of the ocean may be heated by magma or similar and then it will be less dense, floating upwards to the surface. Along the way it will mix and cool, leading to dispersal of the dissolved salts.
The only way I can imagine a planet with a solid subsurface completely coated in freshwater would be if the planet snowballed hard, no radioactive materials left in the core making heat, no significant tidal pull on the core, and then after reaching a very cold temperature having slow addition of clean water from comets. That said, comets are dirty, they have lots of stuff, so you would need somehow clean comets. Still, at that point once sufficient water has hit the surface it could form a thick enough layer over the salty ocean below and start to melt, maybe from greenhouse effects. As soon as it runs away and keeps heating enough it will start to melt the core ice though, so you could have a short lived window in that freak occurrence but it will be very temporary and not at all likely.
So we're doing breams now?
When you need a component such as the .NET framework you can install it in Wine/Proton using the Windows installers. The .exe you are being recommended should be able to run, but the other way around it is to use something like protontricks, a proton version of winetricks (technically it uses winetricks and is more of a set of integrations and a GUI, but yeah). Using protontricks you can install the .NET framework, the C++ runtimes, dxvk, and other tools. I would recommend learning a little about how to use protontricks and maybe look for a few specific tutorials for using it with specific games to get a feel for it.