this post was submitted on 12 Jul 2024
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science

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[–] [email protected] 40 points 3 months ago (1 children)

If mice ever become the dominant species, they're going to start off so overpowered with advancements in medical treatments.

[–] [email protected] 6 points 3 months ago

Man you don't even know, we probably have immortal mice at this point

[–] [email protected] 21 points 3 months ago (2 children)

I'm convinced that the Alzheimer's field is one of the areas of research that will be looked back upon with disillusionment.
Tau tangles and beta plaques have been fiercely and dogmatically pursued as causes and therapeutic targets of Alzheimer's disease. However, it is becoming increasingly clear that these aggregations are likely a consequence of the disease that does not necessarily present an avenue for therapy. I.e. the harmful part of the disease probably acts upstream of or in parallel to the accumulation of the tau and beta aggregations

[–] [email protected] 25 points 3 months ago (1 children)

All because Sylvain Lesné and team published a fraudulent research paper in 2006. The field has possibly lost a decade of time and money.

[–] [email protected] 9 points 3 months ago

TIL. Damn.

Reminds me of the how early the covid policies were based on age-old misconceptions about aerosols.

[–] [email protected] 2 points 3 months ago

How do you explain that amyloid-targetting therapies are seeing some success, even if limited?

[–] [email protected] 21 points 3 months ago (1 children)

I feel like I've heard that clearing the tangles really doesn't affect the trajectory of the disease?

[–] [email protected] 27 points 3 months ago

Yeah, from the article "while many tau-based therapies show promise in animal models, their translation into effective medicine for humans 'has so far failed.'".

[–] [email protected] 7 points 3 months ago

Well, I'm certainly glad there a nasal spray that deals with the toxic mice tangles in my nose.