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New Alzheimer's Nasal Spray Clears Toxic Tangles in Human Neurons And Mice (www.sciencealert.com)

submitted 3 months ago by [email protected] to c/[email protected]

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[–] [email protected] 21 points 3 months ago (2 children)

I'm convinced that the Alzheimer's field is one of the areas of research that will be looked back upon with disillusionment.
Tau tangles and beta plaques have been fiercely and dogmatically pursued as causes and therapeutic targets of Alzheimer's disease. However, it is becoming increasingly clear that these aggregations are likely a consequence of the disease that does not necessarily present an avenue for therapy. I.e. the harmful part of the disease probably acts upstream of or in parallel to the accumulation of the tau and beta aggregations

[–] [email protected] 25 points 3 months ago (1 children)

All because Sylvain Lesné and team published a fraudulent research paper in 2006. The field has possibly lost a decade of time and money.

[–] [email protected] 9 points 3 months ago

TIL. Damn.

Reminds me of the how early the covid policies were based on age-old misconceptions about aerosols.

[–] [email protected] 2 points 3 months ago

How do you explain that amyloid-targetting therapies are seeing some success, even if limited?