Remember this is a business issue for Reddit- by removing your content, you are making their database less valuable. You should assume the edit and delete system is actively hostile to this sort of activity.
To that end, I don't suggest deleting at all. Deleting a lot of comments is a big red flag. As is any kind of automated activity like doing one every 5 seconds.
I would also suggest, if you want to devalue the database as quickly as possible, don't bother doing all of your comments. Do the ones that are most popular. And don't delete them, edit them. Whatever edits you put in should be coherent sentences so a spelling and grammar check would not flag them. And don't do one every 5 seconds, do one every 5 minutes.