World News

22056 readers

75 users here now

Breaking news from around the world.

News that is American but has an international facet may also be posted here.

Guidelines for submissions:

Where possible, post the original source of information.
- If there is a paywall, you can use alternative sources or provide an archive.today, 12ft.io, etc. link in the body.
Do not editorialize titles. Preserve the original title when possible; edits for clarity are fine.
Do not post ragebait or shock stories. These will be removed.
Do not post tabloid or blogspam stories. These will be removed.
Social media should be a source of last resort.

These guidelines will be enforced on a know-it-when-I-see-it basis.

For US News, see the US News community.

This community's icon was made by Aaron Schneider, under the CC-BY-NC-SA 4.0 license.

founded 2 years ago

MODERATORS

[email protected]

288

New research underscores benefits of gender-affirming hormones, rebutting anti-trans claims (www.statnews.com)

submitted 1 year ago by [email protected] to c/[email protected]

31 comments fedilink hide all child comments

Actual evidence from actual scientists.

[Image description: A patient holds bottles of medications for hormone replacement therapy as part of her gender-affirming care.]

you are viewing a single comment's thread
view the rest of the comments

[–] [email protected] 2 points 1 year ago

Thanks for that.

Lack of blinding is a serious issue for subjective outcomes but blinding when treatment effects are obvious to both intervention and control groups is dishonest (Pharma does it all the time to make their trials look more credible than they are).

Open label is the norm for cancer trials for exactly this reason. It is important to consider the biases that may arise, in subjective endpoints especially. But it is ludicrous to dismiss research on this basis alone. We can't randomise 12 year olds to become lifetime smokers or not, let alone use placebo controls, but we do know that smoking kills. It's just a bit more complicated to prove it when perfectly designed RCTs are not possible.