In my setting if someone was born blind, paralyzed, etc, Regeneration wouldn't fix it. Regenerate brings you back to your normal state, which even your perceived self plays a role in.

For example the blind man mentioned in my post description) lost his eye sight decades prior. He has fully accepted his blindness to the point his perceived self is blind. A wandering adventurer tried to cast Regenerate on him to heal the old mans wounds he sustained helping the adventurer in a time of need years prior and when it failed to work on his eye sight the old man informed him that it's who he was. "The helpful old blind man bring aid to those that need it." And the old man continued on his way happier knowing he helped someone else that day.