niucllos

Oh God, I was imagining one of his weird motions that sort of looks like a hand job but isn't supposed to, but yeah this is super deliberate.

Sure, there will be examples of problems in any field that has hundreds of thousands to millions of humans working in it. That doesn't mean there's a broad crisis, and it doesn't mean that most research is faked or fallible. In your 2004 example, all of the data wasn't faked, some images for publication were doctored. There's been potential links between alzheimer's and aBeta amyloids since at least 1991 (1), long before this paper that posited a specific aB variant as a causal target. Additionally, other Alzheimer's causes and treatments are also under investigation, including gut microbiome studies since at leasg 2017 (2). Finally, drugs targeting aB proteins to remove brain plaques work in preclinical trials, indicating that the 2004 paper was at least on the right track even if they cheated to get their paper published. This showcases science working well: bad-faith actors behaved unethically, but the core parts of their work were replicated and found to be effective, so some groups followed that to clinical trials which are still ongoing, and others followed other leads for a more holistic understanding of the disease.

Also, I'd very much argue that human neurological diseases are both bleeding edge and niche, which inherently means that recognizing problems in studies will take more time than something that is cheaper or faster to test and validate, but problems will eventually be recognized as this one was.

1. Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, Perry G. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci USA. 1991;88:7552–6.
2. Cattaneo, A. et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol. Aging 49, 60–68 (2017).

I wouldn't call it a broad crisis, and it isn't universal. More theoretical sciences or social sciences are more prone to it because the experiments are more expensive and you can't really control the environment the way you can with e.g. mice or specific chemicals. But most biology, chemistry, etc that isn't bleeding edge or incredibly niche will be validated dozens to hundreds of times as people build on the work and true retractions are rare

A pride flag pin is not political swag but also correlates very strongly to voting blue, and far-right nutjobs could run with that

Also, a lot of shops, especially used ones, want you to be a repeat and happy customer so will work with you on what you want. Go in and ask for something easy to work on and they'll help with that

I think she's using it less as therapy and more as a way to win arguments is the problem

No, the Republicans also don't have the power to fix the system. That's not their goal. Both parties have the power to completely gum up the works of the government, which is antithetical to fixing the system, but is perfectly acceptable if your goal is to weaken protections to allow a privileged few to gain more power through extragovernmental levers. If we entered a mirror world where the Democratic party were gunning to be a fascist dictatorship and the Republicans were gunning to stop them, but all voters retained their current alliances, not much would change long-term because there are enough people in both parties to obstruct and roadblock, unless the now-pro-civil-rights supreme court kept being radical but in a positive direction

I mean there's been a lot to help corporations and the rich I don't agree with but the current administration has also given tons of resources to the IRS to claw back evaded taxes from the wealthy, made moves to bust monopolies and price-fixing practices, and while they aren't directly responsible there has been a historic expansion of unions not seen in my lifetime

My aunt is a big gardener in 7a (piedmont NC) and has overwintered jalapenos a few times and declared it not worth it for her, apparently the yields aren't much/any bigger than new seedlings and it's a nontrivial amount of work and space to keep them overwintered. If you try again and have different results I'd love to hear about it!

*all new cars

I'm not saying me driving an EV does statistically anything to reduce carbon emissions, or even that if I got all my friends and family to go vegan and bike instead of drive cars that it would. I am saying that the broad public doesn't care about these issues enough to consume differently or vote for policy or politicians that make their lives less convenient in order to fight climate change, and that instead our individual actions to avert climate change contribute to a public ethos that can accept lifestyle changes and that may potentially hold the mega polluting corporations to account and fix our throw-away durable goods culture in a way that media-demonized protests and pestering bought-and-paid politicians never can.

While this is basically true, what it ignores is the impact personal decisions make on the ethos around us to build support for legal pressure. I have family that doesn't disbelieve climate change but isn't motivated by it, and by us going mostly meatless and buying and EV they've started meatless Mondays and Thursdays and are considering an EV for their next car. Our individual actions ripple out, and create a public normalization for these types of changes so that it isnt an uphill battle to get uninformed laypeople to care about climate policy at the polling stations