Empiricism is a narrower concept. It requires one to setup a system which defines "evidence", "verification", and a criterion for "true knowledge", and probably more. Afaik, Marx did not busy himself with this, and both him and Engels did not like the static manner in which British empiricism treats knowledge and reality.
While this "materialism" might sound positivistic, it isn't just merely about empirical evidence (where do raw senses stop and interpretive perception starts?) but rather it's more about aligning and rationalising our cognition as to make sense of everything (myself and everything else); to encompass as much of the whole and not only selective parts of it that bode well to our feelings and will-to-power (like superstitions or irrationalism, or fascism).
At this point I've strayed far from existence and "true meaning", which you've discussed under the CW section. You mentioned physicalism and lost of "meaning", and idealism, or turning to the primacy of minds, as an existential escape from this. Here, you come round to justify meaning with inferences from seeing others. Not that there's anything inherently wrong with that, but some will take issue in analytical philosophy of minds and the like, with all kinds of problems: hard problem of consciousness, problem of other minds (solipsism) etc.
You've mentioned meaning quite a lot that I think you should additionally look at phenomenology for the existential question, maybe with Merleau-Ponty, then all kinds of feminist philosophy, metaphilosophy, hermeneutics, philosophy of history etc.
I have found this top down approach more empowering than looking for answers to life within the rigid framework of (often white men's) Anglo philosophy that, from bottom up, relies too heavily on the existential quantifier, a literal logical notation, to more fully deliver meaning to life.
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