overview for fermionsnotbosons

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Favorite reaction you've done/studied in the past 6 months? (lemmy.world)

submitted 1 year ago by [email protected] to c/[email protected]

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I assume anyone who comes here will either have completed a reaction or studied one (computationally, in a course, for fun, etc.) recently, so why not share favorites? Include why you liked it best, if you feel like elaborating!

I'll go first.

Mine might be the reaction of an oxime (in dichloromethane) with an O-protected propargylic alcohol, using bleach and triethylamine. The oxime gets converted into a nitrile oxide by the bleach and base, and then undergoes a 3+2 cycloaddition with the alkyne to produce an isoxazole VERY cleanly. Work-up of this biphasic reaction consisted of partitioning the phases and concentrating the organics (after a weak acid wash and silica plug), resulting in publication-quality NMR data without further purification going into the next step! Very good for me as it is a key precursor that needs to be made in very large (for R&D) quantities.

It's not super fancy by any means, but I love cycloadditions, heterocycles, and reactions that are successful with minimal byproducts (don't we all?), lol.

Catsubs for the threadiverse! by fermionsnotbosons in c/[email protected]

[-] [email protected] 2 points 1 year ago

Thank you for doing this, now I can more effectively manage my cat community subscriptions to get the perfect ratio of cat to everything else!

Disconcerting responses on Reddit over blackout by fermionsnotbosons in c/[email protected]

[-] [email protected] 3 points 1 year ago

I am pretty sure I saw a homelab community on lemmy.ml already, just FYI.

squish. that. cat. by fermionsnotbosons in c/[email protected]

[-] [email protected] 1 points 1 year ago

Cat regret, lol.

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Who dat? (lemmy.world)

submitted 1 year ago by [email protected] to c/[email protected]

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Woke him up from nap #6 that day.

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No cardboard box? No problem, this'll do! (lemmy.world)

submitted 1 year ago by [email protected] to c/[email protected]

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She hears the crinkling sound of the paper bag and comes running from the other room.

Hoping to drive more engagement here, sooooo.... by fermionsnotbosons in c/[email protected]

[-] [email protected] 0 points 1 year ago

On book 9 (Winter's Heart) of the Wheel of Time right now, albeit for the 4th time! If it's your first read of the series I hope you're enjoying it, it's my favorite of all time. Book 11 is one of the very best!

I also just started The Prince of Nothing series, for which I've heard good things. I'll have more to say about it later.

Hoping to drive more engagement here, sooooo.... by fermionsnotbosons in c/[email protected]

[-] [email protected] 1 points 1 year ago

IMO, yes, it was a good first season with some flaws that will hopefully be improved upon just like the first book was good (not great) and definitely improved upon by subsequent entries.

I've read the series 3 times, and am on my 4th read (book 9) right now. Having re-read book 1 in 2019, I had a pretty clear memory of it when the show premiered and was glad to see some repetitive and inconsistent content from book 1 cut and replaced with more integral subject matter (e.g., the warder bond).

Overall, I am most happy to see the world and characters introduced to a larger audience, who seem to be finding the books in the lull between seasons. I also typically give adaptations plenty of leeway to tell the story in a way that works for the new medium. I am psyched to see how they did with season 2.