When I was on it I found it helped with distraction, but not task initiation, and the various dosages made no difference. Given that and some of the side effects I ended up going off it.
Guanfacine handled the task initiation for me, but not the distraction.
For estradiol pills, patches, and gel are your options if you can't do needles.
Pills aren't recommended for over 45s or those with a history of blood clots, due to increased risk of blood clots.