Sure! As the saying goes: soap box, ballot box, ammo box -- in that order. But it's hard work. The crazies are motivated, so we must be too.
Talk to people. Show them that trans people are not demons (most of the time). Make friends. Let them know that these laws hurt you and people like you. Get involved in the community. Contact your elected representative in government. Often. Get other people to do so too. Join or support an activist organization. Get involved in politics. Run for office. Vote! And make sure others do too.
Failing that, emigrate :3