Anime has varied styles just like western animation does. A comedy show won't use that style as the lead of a comedy show, unless mocking that style like Metalocalypse or something. Homer would probably look like a character from Crayon Shin Chan or Genma from Ranma 1/2 or something.

This is like saying if Homer was in a comic and choosing a gritty marvel look instead of newspaper comics.

Homer looks like he’s about to avenge the murder of his family.

Homer is John Fetterman, got it.

His hand is as big as his face.