161
submitted 3 months ago by [email protected] to c/[email protected]

This study focuses on the manipulation of the plexin-B1 protein to enhance the brain’s ability to clear amyloid plaques in Alzheimer’s disease, opening avenues for future therapeutic strategies to potentially halt the progression of the disease

https://www.nature.com/articles/s41593-024-01664-w

top 4 comments
sorted by: hot top controversial new old
[-] [email protected] 31 points 3 months ago

I'm surprised. As I understand it, the Alzheimer's field is starting to recognize that the plaques are likely a result of, rather than a cause of, the disease. And that the cause may be more related to a, potentially microglia related, inflammatory problem in the CNS

[-] [email protected] 25 points 3 months ago* (last edited 3 months ago)

There are sort of two paths in the research. Some are following the Amyloid Plaque route still. There was a bit of kerfuffle with some of the evidence in other studies which was the basis of this route: https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease

Once you're too far down one path of research, you pretty much can't stop, or you risk your entire career, evidence be damned.

[-] [email protected] 11 points 3 months ago

Thanks, that was a good read. It is terrible that some researchers end up committing such scientific fraud. Although I am inclined to blame the involved researchers themselves, ultimately, I believe that inflexible (and insufficient) funding is the real culprit

[-] [email protected] 8 points 3 months ago

I suspect both methods will be necessary. Step A - clean up amyloid. Step B stop excess amyloid production.

this post was submitted on 01 Jun 2024
161 points (97.6% liked)

science

14271 readers
608 users here now

just science related topics. please contribute

note: clickbait sources/headlines aren't liked generally. I've posted crap sources and later deleted or edit to improve after complaints. whoops, sry

Rule 1) Be kind.

lemmy.world rules: https://mastodon.world/about

I don't screen everything, lrn2scroll

founded 1 year ago
MODERATORS