I have never heard of that theory and research. It was really enlightening to read and seems to be pretty logical. I’ll probably revisit that later.

In response to the main article, I have never really been a big believer in the serotonin deficiency theory. In my experience, depression was much more affected by environmental factors. When I found a clearer sense of purpose, had a safe support system, and identified & let go of people that were not helpful to my mental health, things got steadily better. And have remained better. I know medication is necessary in certain cases to maintain mental health, but I would argue that the environmental effects have a larger impact.

This is also just a theory, but I don’t think genetics are as involved as people believe. I think genetics are base, but the genetics of depression are often really more of learned behaviors that are passed on from parents. Again, I’m positive there are some cases, but not the majority.

nice writeup https://www.science.org/content/blog-post/how-antidepressants-work-last