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this is a topic i've been heavily involved with because i still consider myself to be someone who prefers using technology at a very beginner friendly level, plus it's very good when a linux operating system makes you feel right at home when it has a modern desktop environment. this is why i really like gnome, its simplicity and usability is something available for everyone, for beginners and for a lot of other people, but if you had to, say, rearrange xfce or kde for someone who was an elderly person or an absolute beginner so that they wouldn't have any trouble using linux, how would you do it? (screenshot is my current linux mint desktop, very simple and extremely user friendly!!!!)
No, Gnome is a non-starter for being as mouse negative as it is. You are very heavily supposed to use Gnome with keyboard shortcuts and it will only sometimes begrudgingly allow you to use the mouse.
I also really want to kick the app drawer in the head. Why is it two operations deep? Why can't it be sorted by category like every other Linux app menu?
I would go with Mint Cinnamon, increase font sizes or UI scaling, switch to the Cinnemenu because it offers bigger square icons rather than a tiny list, turn off a lot of its extra features, and put launchers for commonly used applications on the desktop. Configure updates to automatic, and otherwise sand down a few rough edges and I think you're good to go.