Need to let loose a primal scream without collecting footnotes first? Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid: Welcome to the Stubsack, your first port of call for learning fresh Awful you’ll near-instantly regret.
Any awful.systems sub may be subsneered in this subthread, techtakes or no.
If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post — there’s no quota for posting and the bar really isn’t that high.
The post Xitter web has spawned soo many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.
(Semi-obligatory thanks to @dgerard for starting this.)
found a new movie plot threat https://www.science.org/doi/10.1126/science.ads9158
funded by open philanthropy, but not only and also got some other biologists onboard. 10 out of 39 authors had open philanthropy funding in the last 5 years so they're likely EAs. highly speculative as of now and not anywhere close to being made, as in we'll be dead from global warming before this gets anywhere close from my understanding. also starting materials would be hideously expensive because all of this has to be synthetic and enantiopure, and every technique has to be remade from scratch in unnatural enantiomer form. it even has LW thread by now hxxps://www.lesswrong.com/posts/87pTGnHAvqk3FC7Zk/the-dangers-of-mirrored-life
it hit news https://www.nytimes.com/2024/12/12/science/a-second-tree-of-life-could-wreak-havoc-scientists-warn.html https://www.theguardian.com/science/2024/dec/12/unprecedented-risk-to-life-on-earth-scientists-call-for-halt-on-mirror-life-microbe-research
I read the headline yesterday and thought, "This is 100% fundraising bullshit."
This strikes me as being exact same class of thing OpenAI does when they pronounce that their product will murder us all.
What do we call this? Marketerrorism?
i see how it's critihype but i don't understand where's money in this one
CRITIHYPE, thank you! I couldn't find the word!
If I had to guess a motive, it would be to bring mirror biology out of the obscurity of pure research (who funds that anymore?) and to instead plant it firmly into the popular zeitgeist as a "scary thing" that needs to be defended against. This can lead to it becoming a trendy topic, and therefore fundable by grant-awarding agencies.
as in, funding for writing ratty screeds? because they specifically want to cut funding to d-proteins and such. this also works for fundraising
Maybe I'm being too cynical. It wouldn't be the first time this week that someone drew a spooky picture, would it?
nooo waay
Mirror bacteria? Boring! I want an evil twin from the negaverse who looks exactly like me except right hande-- oh heck. What if I'm the mirror twin?
I'm definitely out of my depth here, but how exactly does a lefty organism bypass immune responses and still interact with the body? Seems like if it has a way to mess up healthy cells then it should have something that antibodies can connect to, mirrored or not. Not that I'm arguing we shouldn't be careful about creating novel pathogens, but other than being a more flashy sci-fi premise I'm not really seeing how it's more dangerous than the right-handed version.
Also I think this opens up a beautiful world of new scientific naming conventions:
they way i understand it, because immune system is basically constantly fuzzing all potentially new things, what is important is how antigen looks like on the surface. what it is made from matters less, and whether aminoacids there are l- (natural) or d- (not) it shouldn't matter that much, antibodies are generated for nonnatural achiral things all the time including things like PEG and chloronitrobenzene. then complement system puts holes in bacterial membrane and that's it, it's not survivable for bacterium and does not depend on anything chiral. normally all components are promptly shredded, it's a good question if that would happen too but, like - this might not matter too hard - there's a way for immune system to smite this thing
the potential problem is that peptides made from d-aminoacids are harder to cut via hydrolases and it's a part of some more involved immune response idk details. there's plenty of stuff that's achiral like glycerol, glycine, beta-alanine, TCA components, fatty acids that mirrored bacteria can feed on without problems. some normal bacteria also use d-aminoacids so normal l-aminoacids should be usable for d-protein bacteria. there's also transaminase that takes d-aminoacids and along with other enzymes it can turn these into l-aminoacids. but even more importantly we're perhaps 30 years away from making this anywhere close to feasible, it's all highly speculative. there's a report if you want to read it https://stacks.stanford.edu/file/druid:cv716pj4036/Technical%20Report%20on%20Mirror%20Bacteria%20Feasibility%20and%20Risks.pdf
also look up cost of these things. unnatural aminoacids, especially these with wrong conformation but otherwise normal are expensive. l-tert-leucine is unnatural but can be made in biotechnological process, so it's cheaper. for example on sigma-aldrich, d-glutamine costs 100x more than l-glutamine, and for sugars it's even worse because these have more chiral centers
besides, it's not really worth it probably? it will take decades and cost more than ftx wiped out. other than making it work just to make it work, all the worthwhile components can be made synthetically, maybe there's some utility in d-proteins, more likely d-peptides, tiny amounts of these can be made by SPPS (for screening) and larger in normal chemical synthesis (for use). these might be slightly useful if slowed down degradation of peptides could be exploited in some kind of pharmaceutical, but do you know how we can make it work in other way? don't put amide bonds there in the first place and just make a small molecule pharmaceutical like we can do (as in, organic chemists)
another part of the concern is that these things could transform organic carbon in form unusable to other organisms. but nature finds a way, and outside of fires etc, there are bacteria that feed on nylon and PET, so i think this situation won't last long