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They've been in use since I was a child, so like 20 years ago at least, and were often used to delay puberty when it started abnormally early for a child. They're perfectly fine.
If we want to talk specifically about the drug transphobes shit their pants over, Lupron, it has been in use since the mid-80s. And studies have shown that Lupron as well as other puberty blockers are, by and large, safe for kids. We have like 40 years of data on this.
Using them for that purpose is fine.
Using them to hold back puberty in children who believe they are trans has SEVERE medical repercussions.
That's only possible if there's a physiological difference between someone trans and someone who isn't trans, that's present without any treatment. If trans people are distinctly different physiologically with all other things equal, that confirms the need for medicine and treatment. Your argument is still defeating.