The drama and chaos in the Class of 09 game really makes me wonder how the Azumanga cast would react. The settings are also similar: both take place in a 2000s high school.
For those that don't know what class of 09 is, https://www.youtube.com/watch?v=Z1jvXZ-Tqc4 should give you an idea.
Personally:
Osaka gets bullied often
Chiyo barely survives
Sakaki attempts to defend her friends, mainly Chiyo and Osaka
idk for Yomi, probably little/no interaction
Tomo interacts with the main characters almost every school day
Kagura interacts with the main characters about a few times per week, still cares about the rest of the azumanga characters though