I would usually be sad to see another original RPG go 5e compatible but Neuroshima was infamously poorly designed ruleset, possibly worse than Shadowrun. I probably won't be running it, but may steal statblocks for my 5e game if I need weird stuff again.
It can be sorta easy to be casual if you have an extremely knowlgeable dm. I sorta started that way, session 0 and 1 just had him help us build our characters and run a 10 minute solo goblin 'dungeon' where he explained basic rules and possible actions. The moral of the story was that you can do other things beside kill npcs. Turns out if I had attempted to talk to the goblins or even explored the area I would have realized they were orphan goblin children, malnourished and afraid... Instead I slaughtered them all for no reward or reason. One hint was that non of them were armed and they always ran at my sight. Definitely stopped any murder hobo tendencies from developing. After that he did mention our rule book and linked me to read but he could have very well not and we would have chugged along fine. I prefer pathfinder now a days better.