Oh wow, thanks for the details! 10^25^ years ... no, times ... yeah, crazy. I mean, that's beyond homeopathic. Since I learned about this topic as an interested layman, I somehow assumed everything can decay, and we simply call the things "stable" which do so very slowly. Which can mean as many atoms decay over the course of a billion years as there are medically effective molecules in homeopathic "medicine"; none.

Also https://en.wikipedia.org/wiki/Proton_decay

I don't think current understanding of things is that the universe is infinite. We can estimate the size of the universe we know, because we know how fast it is spreading and for how long. Wiki says: "Some disputed estimates for the total size of the universe, if finite, reach as high as 10 10 10 122 10^{10^{10^{122}}} megaparsecs. We don't know whether that's all there is though. We don't even know whether the universe has the same properties everywhere, which complicates things.

Oh yeah for sure, I don't mean at all to say that all questions have been answered, and even the answers that we do have get more and more vague as you move down the science purity ladder. If all questions were solved, we would be out of a job for one! But I choose to interpret OP's question as "is there anything unknowable?". That's the question relevant to our world right now, and I often disagree with the world view implied by popular science - that the world is full of wonder but also mystery. The mystery is not fundamental, but rather an expression of our individual and collective ignorance. There are even plenty of questions, like the delayed-choice quantum eraser, that have already been solved, and yet they keep popping up as examples of the unknowable, one even sniped me in this very thread (hi there!). Then people say "you do not even know whether eating eggs is good for you" and therefore by implication we shouldn't listen to scientists at all. In that sense, the proliferation of the idea of mystery has become dangerous. The answer to unanswered questions is not gnosticism, it is as you said "further research" 😄!

I wouldn't say that Sabine is among the "least biased". She strongly advocates for superdeterminism, and her videos on the subject presume it is true even though it is still unproven and currently accepted only by a minority of physicists.

On the subject of Heisenberg Uncertainty - even there I blame popular science for having misled me! "You can't know precise position and momentum at once" - sounds great! So mysterious! If you dig a little deeper, you might even get an explanation like that to measure the position of something you have to bombard it with particles (photons, electrons), and when it's hit its velocity will change in a way you do not know. The smaller that something is, and the more you bombard it to get more precise position, the more uncertainty you will get.

All misleading! It was not until having taken an actual physics class where I learned how to calculate HU that I realized that not only is HU the result of simple mathematics, but that it also incidentally solves the thousands-years-old Zeno Paradox almost as a side lemma - a really cool fact that I was taught nowhere before!

Basically the wavefunction is the only thing that exists. The function for a single particle is a value assigned to every point in space, the values can be complex numbers, and the Schroedinger equation defines how the values change over time, depending on their nearby values in the now. That function is the particle's position (or rather its square absolute magnitude) - if it is non-zero at more than one point we say that the particle is present in two places at once. What is the particle's velocity? In computer games, each object has a value for a position and a value for a velocity. In quantum mechanics, there is no second value for velocity. The wavefunction is all that exists. To get a number that you can interpret as the velocity, you need to take the Fourier transform of the position function. And you don't get one number out, you get a spectrum.

In one dimension, what is the Fourier transform of the delta function (a particle with exactly one position)? It is a constant function that is non-zero everywhere! (More precisely it is a corkscrew in the complex values, where the angle rotates around but magnitude remains the same). A particle with one position has every possible momentum at once! What is the Fourier transform of a complex-valued corkscrew? A delta function! Only a particle that is present everywhere at once can be said to have a precise momentum! The chirality of the particle's corkscrew position function determines whether it is moving to the left or to the right. Zeno could not have known! Even if you look at an infinitesmall instant of time, the arrow's speed and direction is already well-defined, encoded it that arrow's instantaneous position function!

If you try imagine a function that minimizes uncertainty in both position and momentum at once, you end up with a wavepacket - a normal(?)-distribution-shaped curve peak that is equally minimally wide in both position and momentum space. If it were any narrower in one, it would be way wider in the other. That width squared is precisely the minimum possible value of Heisenberg Uncertainty in that famous Δx*Δp >= ħ/2 equation. It wasn't ever about bombardment at all! It was just a mathematical consequence of using Fourier transforms.

The uncertainty principle fundamentally can't fall. It's not a limitation of our measurement devices, it's a fundamental limitation of physics that, as far as we know, can't be broken.

Also, Sabine Hossenfelder has horrible takes regarding trans people, so I'd take anything from her beyond her immediate field with a giant grain of salt.